中图分类号:
R914.2
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参考文献
[1] LAN P, ZHANG D M, CHEN W M, et al. Advances in the study of structural modifications and biological activities of betulinic acids . Acta Pharm Sin (药学学报), 2010, 45(11): 1339-1345.[2] FRANZISKA B M, JAN H K, JAN P M. Betulinic acid, a natural compound with potent anticancer effects . Anti Cancer Drugs, 2010, 21(3): 215-227.[3] ARNAB R C, SUPARNA M, BIDYOTTAM M, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: Identification of the inhibitory step, the major functional group responsible and development of more potent derivatives . Med Sci Monit, 2002, 8(7): 254-260.[4] FENG W J. Advances of topoisomerase I inhibitors . Hebei Med J(河北医药), 2001, 23(4): 243-244.[5] YANG M,WANG G J, XU Y P,et al. Intestinal absorption and mechanism of 23-hydroxybetulinic acid using Caco-2 monolayer model. Chin Pharm J(中国药学杂志), 2008,43(5):349-352..[6] YE W C, JIN N, ZHAO S X, et al. Triterpenoids from Pulsatilla Chinensis . Phytochemistry, 1996, 42(3) : 799-802.[7] JI Z N, YE W C, LIU G G, et al. 23-Hydroxy betulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 cells . Life Sci, 2002, 72(1): 1-9.[8] TAN J J, WANG Y, WANG C X. Quantitative structure-activity relationship of anti-HIV fusion inhibitors by topomer CoMFA. J Beijing Univ Technol(北京工业大学学报), 2013, 39(2): 309-313.[9] XIANG Y H, JIANG D P, ZHANG Z Y. Studied on benzamide hydroxamic acid histone deacetylase inhibitors (HDACI) by molecular docking and CoMFA. Comput App Chem, 2009, 26(11): 13741- 1379. BI Y, XU J Y, SUN F, et al. Synthesis and biological activity of 23-hydroxybetulinic acid C-28 ester derivatives as antitumor agent candidates . Molecules, 2012, 17(8):8832-8841. BI Y, XU J Y, SUN F, et al. Synthesis and antitumor activity of 17-carboxylic acid modified amide derivatives of 23-hydroxy betulinic acid . Rec Nat Prod, 2010, 4(4): 176-179. BI Y, XU J Y, SUN F, et al. Synthesis and biological activity of 28-amide derivatives of 23-hydroxy betulinic acid as antitumor agent candidates. Med Chem, 2013, 9(7):920-925. WOLD S, SJSTRM M, ERIKSSON L. PLS-regression: A basic tool of chemometrics. Chemometr Intell Lab Syst Lab Inf Manage, 2001, 58(2): 109-130. CRAMER R D, BUNCE J D, PATTERSON D E, et al. Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies. Quant Struct Act Relat, 1988, 7(1): 18-25. FATMA M, ABDEL B A R, MOHAMMAD A, et al. Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors . J Nat Prod, 2009, 72(9):1643-1650. LEVENT S, IOAN A. Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxation . Nucleic Acids Res, 2005, 33(20): 6621-6634. SONG Y L, ZHANG W N, JI H T, et al. Structure and function of DNA topoisomerase Ⅰ with the development of camptothecin drugs. Chin Pharm J(中国药学杂志), 2002,37(9):646-650. SONG Y L, ZHANG W N, JI H T, et al. Flexible molecular docking studies of antineoplastic camptothecin derivatives on DNA-topoisomerase I complex .Acta Chem Sin(化学学报), 2003, 61(11): 1860-1866. FU X D. Computer-Aided Design,Synthesis and Antitumor Activities of Novel DNA Topoisomerase I Inhibitors. Wenzhou: Wenzhou University, 2010.
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脚注
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基金
国家自然科学基金资助项目(81001358,81273377);2014年烟台大学研究生科技创新基金项目重点项目(YJSZ201420);2013年度烟台大学青年基金项目
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